Research area

Cancer Biology

Apoptosis, angiogenesis, proliferation and oxidative stress in cancer cell models.

Cyclin A (green) and cyclin-dependent kinase 2 (blue) with ATP (magenta). — David Goodsell, RCSB PDB · CC BY 4.0

Overview

Many postgraduate projects test whether an extract, compound or cell-derived product affects cancer cell growth. The strongest studies combine several complementary readouts — viability, apoptosis markers, proliferation and pathway proteins — rather than relying on a single assay.

Questions we can help you answer

Which cell lines and normal-cell controls are appropriate?
How do I choose concentrations and time points?
Which apoptosis markers should be measured together?
How should IC50 values be calculated and reported?

Methods we advise on

Cell viability and cytotoxicity assays
Annexin V, p53 and caspase readouts
VEGF and angiogenesis markers
Oxidative-stress assays
Gene and protein expression

Please note

In vitro anticancer activity does not show that a substance treats cancer in people.

Relevant services

This painting shows a cross-section through an Escherichia coli cell. The characteristic two-membrane cell wall of gram-negative bacteria is shown in green, with many lipopolysaccharide chains extending from the surface and a network of cross-linked peptidoglycan strands between the membranes — Goodsell · RCSB PDB · CC BY

Wet-Lab Strategy & Experimental Research Support

Experimental planning, assay design, troubleshooting and interpretation from a scientist with long bench experience. Hands-on work is coordinated only with qualified external laboratories.

For:: Postgraduate students designing or troubleshooting experiments
Lead:: Scientific Lead

Explore service

This painting includes three types of filaments that make up the cytoskeleton: a microtubule (the largest), an intermediate filament (the knobby one), and two actin filaments (the smallest ones). The large blue molecules are ribosomes , busy in their task of synthesizing proteins — Goodsell · RCSB PDB · CC BY

Scientific & Research Consulting

Sharpen the research question, choose a defensible design and plan the work before time and reagents are spent.

For:: Postgraduate researchers and early-career scientists
Lead:: Scientific Lead

Explore service

Structures of nanobodies (green) bound to SARS-CoV-2 spike protein (magenta). — Goodsell · RCSB PDB · CC BY

Computational Biology & Bioinformatics

Docking, network pharmacology and reproducible analysis workflows — with honest limits on what in silico results mean.

For:: MPhil and PhD researchers adding an in silico chapter
Lead:: Scientific Lead

Explore service

Tell us what you’re working on.

Send a short, confidential summary. We reply with an initial scope assessment, and you agree deliverables, timeline and price before anything starts.

Discuss your research